Management of preclinical oncology animal studies

Flexible study definition

The easy study definition includes:

• Associated protocol document
• Any type of measurement for any study phase with target definition: group, animal, tumor. Each measurement can have a 'normal' range in order to get alarms when inconsistent measurements are entered.
• User-defined formulas for any parameter, for example tumor volume
• Irradiations and dose
• Tumor inductions with method and target organ. Can be chemical (agent, fixed or body-weight dependent dose), cells (cell line, cell count, volume) or fragment implants (cell line, tumor fragment weight,...)
• Pre-randomization and treatment groups
• Criteria for automated randomization to allocate animals to groups
• Treatments with drug, concentration, administration route, fixed or body-weight dependent dose
• Sample collections (organ, quantity, collection mode) and autopsies (organ)
• Values to trigger alerts when groups are ready for randomization, or when animals reach sacrifice conditions
• All the tasks can be defined even at the group level, are allocated to an operator and have a user-defined periodicity or can be event-driven (after identification, randomization, death, sacrifice, study end).